盐霉素
腺癌
肺癌
癌症干细胞
A549电池
癌症研究
干细胞
癌症
医学
肿瘤科
内科学
生物
细胞生物学
生物化学
抗生素
出处
期刊:Medicinal Chemistry
日期:2011-03-01
卷期号:7 (2): 106-111
被引量:85
标识
DOI:10.2174/157340611794859307
摘要
Lung cancer is a leading cause of death in human. Cancer stem cells have been regarded as basis for failure of current therapeutic options. Salinomycin was shown to kill these cancer stem cells in some types of cancer such as breast cancer and leukemia. The in vitro anticancer activities of salinomycin have been validated against the lung cancer cell line A549 via sulforhodamine B and colony formation assay. Salinomycin has been demonstrated to significantly rupture the in vitro lung cancer tumorospheres from ALDH positive A549 lung cells using flow cytometry. Expression of stem cell markers OCT-4, NANOG and SOX2 in ALDH positive A549 lung cells was decreased significantly by real-time RT-PCR analysis after 24 hour salinomycin treatment. Taken together, salinomycin may provide a promising approach for lung cancer chemotherapy.
科研通智能强力驱动
Strongly Powered by AbleSci AI