A Theoretical Study on the Relationship Between the Muscle Contraction Force and Contraction Velocity

Objective:Based on the knowledge of special structure of muscle and a mechanochemical actin-activated myosin ATPase cycle four-state model,the relationship between the muscle contraction force and the contraction velocity is discussed.According to up-building a mechanical model,the relationship between the muscle contraction force and the contraction velocity is discussed thoroughly.Methods:With experimental results of single molecule myosin the relationship between the muscle contraction force and the contraction velocity is proposed from the view of physics by the chemical kinetic method and biochemical thermodynamic theory,and the relationship between the muscle contraction force and the contraction velocity is calculated.Results:We find the relationship is similar with the Formula Hill.The theoretical results are consistent with that of experiment.The chemical reaction of muscle contraction is accommodated automatically according to the change of load in muscle,the force of friction is relative to the load in muscle contraction.Conclusions:The model is fit to discussing the relation between the muscle contraction force and the contraction velocity and the method of physics is also fit to studying the system in this article.