Objective:To discuss how to prevent and treat thrombosis of deep vein in lower limb of orthopedic patients.Methods:Patients with fracture of lower limb or prone to thrombosis were systematically treated to prevent them from thrombosis.Results:These patients treated with physical and drug therapy recovered satisfactorily.Conclusion:It is important to prevent orthopedic patients from thrombosis of deep vein in lower limb for improving the curative effect and reducing the occurrence of complications.