多酚
抗癌药
药品
纳米技术
材料科学
药物输送
传统医学
药理学
业务
绿茶
医学
化学
生物化学
食品科学
抗氧化剂
作者
Xiaoli Wang,Xuanling Li,Xiaoyu Liang,Jiayi Liang,Chao Zhang,Jing Yang,Chun Wang,Deling Kong,Hongfan Sun
摘要
Reactive oxygen species (ROS)-responsive nanocapsules for cancer drug delivery were engineered from green tea polyphenol-metal networks. Briefly, DOX-doped ZIF-8 nanoparticles were synthesized via coprecipitation and coated with a layer of EGCG-Fe(iii) complexes by suspending in EGCG and ferric chloride aqueous solutions under mild conditions. The DOX-encapsulating EGCG/Fe nanocapsules (DOX@EGCG/Fe NCs) with a diameter of 399 nm were obtained after template removal. The as-prepared EGCG/Fe NCs can reduce ROS potential accompanied by their degradation. Moreover, DOX@EGCG/Fe NCs can be quickly internalized by cancer cells, and then the intracellular drug release was greatly accelerated in response to overproduced ROS of tumor. Owing to higher ROS levels inside tumor cells compared with normal cells, DOX@EGCG/Fe NCs cause selective cytotoxicity for tumor cells over normal cells. Furthermore, the cytotoxicity of DOX@EGCG/Fe NCs was increased with the increasing incubation time with cancer cells, whereas the tendency of free DOX was reversed. Accordingly, DOX@EGCG/Fe NCs demonstrate good tumor growth inhibition (84.2%) with minor systemic toxicity, which would be a promising candidate for B16 melanoma therapy. Hopefully, our approach could be extended to many other delivery systems such as water soluble/insoluble drugs, gene and protein due to the diversity of polyphenol-metal networks and ZIF-8 templates.
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