四分位间距
医学
心脏病学
内科学
心肌梗塞
置信区间
ST段
闭塞
作者
Niall Morris,Richard Body
出处
期刊:European Journal of Emergency Medicine
[Ovid Technologies (Wolters Kluwer)]
日期:2017-08-01
卷期号:24 (4): 236-242
被引量:42
标识
DOI:10.1097/mej.0000000000000463
摘要
The De Winter ECG pattern has been reported to indicate acute left anterior descending coronary artery occlusion and is often considered to be an ‘ST elevation myocardial infarction (STEMI) equivalent’. We aimed to investigate the morphology of the ‘De Winter ECG pattern’ and evaluate the test characteristics of the De Winter pattern for the diagnosis of acute coronary occlusion. We identified papers through the Medline, EMBASE and COCHRANE databases and screened for bias using QUADAS-2. First, measurements were recorded from every ECG reported in the literature and aggregated. Second, diagnostic accuracy data from eligible cohort studies were extracted. The primary outcome was defined as at least 70% angiographic stenosis of a major epicardial vessel. Thirteen papers reported data relevant to question 1 and three papers reported data relevant to question 2. All ECGs showed maximal up-sloping ST depression in lead V3 with a median amplitude of 0.3 mV (interquartile range: 0.2–4 mV). T-wave height peaked in lead V3 with a median amplitude 0.9 mV (interquartile range: 0.8–1.1 mV). The De Winter pattern had positive predictive values of 95.2% (95% confidence interval: 76.2–99.9%), 100% (69.2–100.0%) and 100% (51.7–100%) in the three respective diagnostic studies. There is limited evidence that the De Winter ECG pattern is a ‘STEMI equivalent’. The available data suggest that the pattern has high positive predictive value for acute occlusion. Further research is required to evaluate specificity and to determine whether rapid revascularization improves mortality.
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