化学
噻嗪
电泳剂
反应性(心理学)
Diels-Alder反应
立体化学
组合化学
药物化学
有机化学
催化作用
医学
病理
替代医学
作者
Giacomo Biagiotti,Laura Legnani,Giusi Aresta,Maria Assunta Chiacchio,Barbara Richichi
标识
DOI:10.1002/ejoc.202200769
摘要
Abstract The synthesis and reactivity in an [4+2] inverse electron demand hetero Diels‐Alder reaction (ihDA) of an original class of electron‐poor heterodienes, the N ‐substituted‐1H‐benzo[c][1,2]thiazin‐4‐one‐2,2‐dioxides, are described. These are highly reactive electrophiles that allow easy access to unprecedented benzo‐thiazine glyco‐fused derivatives in a remarkably selective way, even when using acetylated glycals, previously unexplored within this version of ihDA. DFT calculations support the experimental data, and moreover show that acetylated dienophiles can easily react making cycloadditions feasible.
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