衰老
细胞衰老
细胞老化
老年学
医学
细胞生物学
生物
神经科学
端粒
遗传学
表型
DNA
基因
作者
Yi Zhu,Zacharias P. Anastasiadis,Jair Machado Espindola Netto,Tamara S. Evans,Tamar Tchkonia,James L. Kirkland
出处
期刊:Cold Spring Harbor Perspectives in Medicine
[Cold Spring Harbor Laboratory]
日期:2023-09-21
卷期号:14 (2): a041205-a041205
标识
DOI:10.1101/cshperspect.a041205
摘要
Cellular senescence was initially described in the early 1960s by Hayflick and Moorehead. They noted sustained cell-cycle arrest after repeated subculturing of human primary cells. Over half a century later, cellular senescence has become recognized as one of the fundamental pillars of aging. Developing senotherapeutics, interventions that selectively eliminate or target senescent cells, has emerged as a key focus in health research. In this article, we note major milestones in cellular senescence research, discuss current challenges, and point to future directions for this rapidly growing field.
科研通智能强力驱动
Strongly Powered by AbleSci AI