医学
老化
老年学
生命历程法
健康老龄化
社交生活
联想(心理学)
人口学
发展心理学
心理学
内科学
社会学
心理治疗师
民族学
历史
作者
Xiaojing Liu,Ming Jin,Zeping Yang,Ziyi Zhang,Ninghao Huang,Tao Huang,Nan Li
出处
期刊:Age and Ageing
[Oxford University Press]
日期:2024-11-28
卷期号:53 (12)
被引量:3
标识
DOI:10.1093/ageing/afae272
摘要
Abstract Background Adverse early-life events influence the health with ageing throughout the life course. However, the effects of combined early-life risks on ageing acceleration in adults and the roles of social environment risks remain unknown. Objective To investigate associations of maternal smoking, breastfeeding and birth weight with accelerated biological age (BA), and to explore genetic-predicted effect and mediating effect of social environment risks. Design Population-based prospective cohort. Setting UK Biobank. Subjects 151 773 participants. Methods We used Klemera–Doubal BA (KDM-BA), PhenoAge and leukocyte telomere length (LTL) as BA biomarkers. Associations of early-life risk factors and score with BA acceleration were estimated using linear regression models. Genetic risk score (GRS) was calculated based on genetic variations for maternal smoking and birth weight. Polysocial risk scores (PsRS) for each BA were calculated by summing the number of dichotomised social environment factors significantly associated with each of the three BA biomarkers. Results Maternal smoking, non-breastfeeding and low birth weight were individually associated with BA acceleration. The early-life risk score was significantly associated with accelerated KDM-BA and PhenoAge and shorter LTL. The effects of GRS on accelerated BA were in the same direction. The BA-specific PsRS mediated the accelerated KDM-BA and PhenoAge and shorter LTL by 8.37%, 22.34% and 7.90%, respectively. Conclusions Our findings demonstrated a dose-dependent association of combined early-life risks with accelerated BA in middle-aged and older adults, partially mediated by social environment risks. The findings highlight the importance of early identification and surveillance of high-risk individuals for ageing acceleration during adulthood.
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