A bio-degradable, triboelectric self-stimulated herbal transdermal therapeutic dressing for healing massive chronic wound

Homogeneous controlled release of active ingredients, avoiding secondary damage of dressing changes would be considerable advance for transcutaneous drug delivery treatment. Here, a bio-degradable, self-stimulated herbal transdermal therapeutic dressing (irritability) driven by multi-ball nimble-rolling triboelectric nanogenerator (mbnr-TENG) is proposed that provided a stable and adjustable triboelectric field for controlling drug release. The mbnr-TENG deliver a periodic triboelectric field of 140 V for herbal dressings by collecting human mechanical energy to enhance transdermal properties of total flavonoids and chlorogenic acid in ss-HTTD by 310% and 147%. Following a therapeutic cycle using ss-HTTD, the secretion of inflammatory factors decreased by 50.35%, and wound healing rate increased by 24.98%, then completely degraded after 10 days. As a new drug delivery system, this work holds great potential in healing massive chronic wound, ss-HTTD is advantageous in controlling drug release, enhancing the activity and the long-term stability of herbal medicines.