Nonthermal plasma (NTP) technology, as an emerging and promising technology, has been exploited for a variety of applications, including material synthesis, surface modification, and the removal of pollutants from air and water. In line with these high-value achievements, a wide range of chemical reactions have been activated by NTP due to its high stability and efficiency. Nevertheless, NTP can be considered an alternative approach for implementing reactions, particularly those that suffer from harsh conditions in conventional techniques. Moreover, the combination of NTP with various catalysts in some chemical reactions has demonstrated significant enhancement in both the conversion of the reactant and the selectivity of the desired product. This review provides an overview of the accomplishment of various chemical reactions, such as oxidation, reduction, copolymerization and polymerization, elimination, addition, isomerization, and rearrangement reactions, in NTP systems. Additionally, it explores the possible mechanisms underlying these reactions by examining the species generated in the plasma atmosphere.