Digital data explosion drives a demand for robust and reliable data storage\nmedium. Development of better digital storage device to accumulate Zetta bytes\n(1 ZB = $10^{21}$ bytes ) of data that will be generated in near future is a\nbig challenge. Looking at limitations of present day digital storage devices,\nit will soon be a big challenge for data scientists to provide reliable.\naffordable and dense storage medium. As an alternative, researcher used natural\nmedium of storage like DNA, bacteria and protein as information storage\nsystems. This article discuss DNA based information storage system in detail\nalong with an overview about bacterial and protein data storage systems.\n