High‐Frequency rTMS Improves Visual Working Memory in Patients With aMCI: A Cognitive Neural Mechanism Study

Patients with aMCI experience significant deterioration in VWM function, particularly during the encoding phase. This deterioration manifests in reduced accuracy and capacity of memory performance, accompanied by a significant decrease in N2pc amplitude, alpha oscillations, and theta-band connectivity in frontoparietal and fronto-occipital brain regions. rTMS proves to be a promising intervention that improves VWM, attention, and executive functions. In particular, it supports attention during target selection by increasing N2pc amplitude during encoding, enhancing alpha oscillations for better suppression of irrelevant information, and increasing synchronization in frontoparietal and occipital functional connectivity, which ultimately improves visual working memory.