Yiqi Huoxue Yangyin Decoction attenuates diabetic nephropathy in db/db mice by modulating METTL3-mediated m6A methylation of mTOR to restore podocyte autophagy

YHY, a traditional Chinese medicine formula with defined chemical metabolites, ameliorates podocyte damage in DN by activating autophagy via the METTL3-m6A-mTOR signaling pathway. This study provides novel insights into the epigenetic regulation of DN and underscores the potential of YHY as a therapeutic agent for this condition.