双环分子
化学
烯烃
环加成
丁烷
范围(计算机科学)
拉伤
立体化学
药物化学
组合化学
有机化学
催化作用
计算机科学
程序设计语言
医学
内科学
作者
Renyu Guo,Yu‐Che Chang,Loïc Herter,Christophe Salomé,Sarah E Braley,Thomas C. Fessard,M. Kevin Brown
摘要
Saturated bicycles are becoming ever more important in the design and development of new pharmaceuticals. Here a new strategy for the synthesis of bicyclo[2.1.1]hexanes is described. These bicycles are significant because they have defined exit vectors, yet many substitution patterns are underexplored as building blocks. The process involves sensitization of a bicyclo[1.1.0]butane followed by cycloaddition with an alkene. The scope and mechanistic details of the method are discussed.
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