Effect of different intensity aerobic exercise on serum NO signal and relative factory in artherosclerosis rat

Objective:Explore the effect of different intensity aerobic exercise on serum NO signal and relative factory in artherosclerosis rat.Method:60 rats were divided into five groups including C group(control group),AS group(artherosclerosis),ASL group(artherosclerosis and low intensity aerobic exercise),ASM group(artherosclerosis and Moderately intensity aerobic exercise) and ASH group(artherosclerosis and high intensity aerobic exercise),and each group has 10 rats.The speed of three exercising groups design as 10m/min,15 m/min and 20 m/min,lasting 30 min.The experiment of exercise persist four weeks,6 days of each week.After the experiment of exercise all rats should be killed and the concentrateion of serum NO,NOS,ET,L-Arg and ADMA should be measured.Result:1.All kinds of exercise intensities can notable improve the concentration of serum NO,however,the effect is more obviously when the intensity exceed medium intensity.Moderately intensity aerobic exercise can obviously improve the serum NOS content.When the intensity exceed medium intensity,the effect of ET concentration increase is more obvious than the low intensity aerobic exercise.2.The concentration of L-Arg is not chang during artherosclerosis developing.All kinds of intensity exercise can not increase the L-Arg concentration.On the other hand,higher intensity aerobic exercise can depress the serum concentration of ADMA and visible improve the ratio of L-Arg/ADMA.Therefore,the higher intensity of aerobic exercise can obviously improve the NO release of artherosclerosis rat.Conclusion: The effect of improve NO signal and relative factory in artherosclerosis rat is most obviously when those rats execute aerobic exercise over Moderately intensity.