Clinical Analyses of Pregnancy Complicated with Genital Human Papillomavirus Infection

Objective:To determine the clinical characteristics,diagnosis and treatment of genital human papillomavirus(HPV) infection during pregnancy and whether people have persistent HPV infection may pregnant.Methods:Forty-five pregnant women with genital HPV infection in PUMCH were analyzed retrospectively.Results: In these forty-five patients with genital HPV infection,26(58%) cases of genital warts,18(38%) subclinical infection,and 1(4%) latent infection with positive HPV-DNA but no any symptom and pathological changes.10(22%) patients were involved simultaneously other genital infection.Only 16(36%) patients received treatment of drug,laser,cryosurgery or surgery.39 patients,including 3 patients with persistent HPV infection had full-term pregnancy.No respiratory papillomatosis cases were identified in all newborns.3 patients kept genital warts in the postnatal recheck.13 patients had thinprep cytological test again and 4 were abnormal.5 patients had hybrid capture(HC2) again and 2 were positive.Conclusions: Prevalence of respiratory papillomatosis is rare in newborn with maternal genital HPV infection that often complicated with other genital infection.The patients with persistent HPV infection may pregnant when virus burden is low.