Correlation between nitric oxide snd essential hypertension and left ventricular hypertrophy

Objective To investigate the correlation between nitric oxide(NO)and essential hypertension(EH)and left ventricular hypertrophy(LVH).Methods NO and left vemricular mass index(LVMI)were measured in 30 patients with EH(EH group),30 patients with EH and LVH(EH+LVH group),and 30 normal controls(NC group).The results were treated by analysis of variance and correlation.Results 1.NO level in EH+LVH group was lower than that in NC and EH groups,and it was lower in EH group than that in NC group,while LVMI level was higher in EH+LVH group(P0.01);2.There was a negative correlation between blood pressure and NO,while there was a positive correlation between blood pressure and LVMI,and a negative correlation between NO and LVMI(P0.01 or0.05). Conclusions NO was involved in the pathophysiological process of EH or EH+LVH.