Nintedanib plus Sildenafil in Patients with Idiopathic Pulmonary Fibrosis

In patients with IPF and a Dl_CO of 35% or less of the predicted value, nintedanib plus sildenafil did not provide a significant benefit as compared with nintedanib alone. No new safety signals were identified with either treatment regimen in this population of patients. (Funded by Boehringer Ingelheim; INSTAGE ClinicalTrials.gov number, NCT02802345 .).