再生医学
神经科学
纳米载体
再生(生物学)
药物输送
医学
细胞疗法
纳米技术
中枢神经系统
干细胞
生物
材料科学
遗传学
细胞生物学
作者
Christina L. Nemeth,Amena Smith Fine,Ali Fatemi
标识
DOI:10.1016/j.addr.2019.05.003
摘要
The focus of regenerative therapies is to replace or enrich diseased or injured cells and tissue in an attempt to replenish the local environment and function, while slowing or halting further degeneration. Targeting neurological diseases specifically is difficult, due to the complex nature of the central nervous system, including the difficulty of bypassing the brain's natural defense systems. While cell-based regenerative therapies show promise in select tissues, preclinical and clinical studies have been largely unable to transfer these successes to the brain. Advancements in nanotechnologies have provided new methods of central nervous system access, drug and cell delivery, as well as new systems of cell maintenance and support that may bridge the gap between regenerative therapies and the brain. In this review, we discuss current regenerative therapies for neurological diseases, nanotechnology as nanocarriers, and the technical, manufacturing, and regulatory challenges that arise from inception to formulation of nanoparticle-regenerative therapies.
科研通智能强力驱动
Strongly Powered by AbleSci AI