抗菌剂
萜类
生物
抗生素耐药性
抗生素
微生物学
生物技术
传统医学
植物
医学
作者
Dorota Jakubczyk,Francois Dussart
出处
期刊:Molecules
[MDPI AG]
日期:2020-02-18
卷期号:25 (4): 911-911
被引量:65
标识
DOI:10.3390/molecules25040911
摘要
Fungal natural products and their effects have been known to humankind for hundreds of years. For example, toxic ergot alkaloids produced by filamentous fungi growing on rye poisoned thousands of people and livestock throughout the Middle Ages. However, their later medicinal applications, followed by the discovery of the first class of antibiotics, penicillins and other drugs of fungal origin, such as peptidic natural products, terpenoids or polyketides, have altered the historically negative reputation of fungal "toxins". The development of new antimicrobial drugs is currently a major global challenge, mainly due to antimicrobial resistance phenomena. Therefore, the structures, biosynthesis and antimicrobial activity of selected fungal natural products are described here.
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