钠通道
化学
药理学
钠
纳米技术
材料科学
医学
有机化学
作者
Shaoyi Sun,Charles J. Cohen,Christoph M. Dehnhardt
出处
期刊:Pharmaceutical patent analyst
[Newlands Press Ltd]
日期:2014-09-01
卷期号:3 (5): 509-521
被引量:37
摘要
There has been intense interest in developing inhibitors of the sodium channel Nav1.7 because genetic studies have established very strong validation for the efficacy to alleviate both inflammatory and neuropathic pain. This review summarizes patent applications targeting Nav1.7 since 2010 until May, 2014. We have classified the patents into three categories as follows: small molecules with well-defined molecular selectivity among sodium channel isoforms; biologicals with well-defined molecular selectivity; and, small molecules that inhibit Nav1.7 with unknown molecular selectivity. Most of the review is dedicated to small molecule selective compounds.
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