医学
甲状腺癌
碘化钠转运体
甲状腺间变性癌
甲状腺
癌症研究
甲状腺髓样癌
癌症
前列腺癌
共转运蛋白
内科学
肿瘤科
病理
运输机
化学
基因
生物化学
作者
Friederike Eilsberger,Andreas Pfestroff
出处
期刊:Pet Clinics
[Elsevier]
日期:2021-07-01
卷期号:16 (3): 375-382
被引量:3
标识
DOI:10.1016/j.cpet.2021.03.007
摘要
The main targeting structure for theranostics in thyroid cancer is the sodium-iodine symporter (NIS), which has been used in clinical routine for the diagnosis and treatment of thyroid diseases for more than 70 years. Because the different iodine (I) nuclides (123I, 124I, 131I) have the same kinetics, uniquely congruent theranostics are possible in differentiated thyroid cancer. Besides the NIS, there are further possibilities by using expression of somatostatin receptors or the expression of the prostate-specific membrane antigen, for example, in radioiodine-refractory differentiated thyroid cancer, medullary thyroid cancer, or anaplastic thyroid cancer.
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