多细胞生物
分区(防火)
有机体
生物信息学
生物
系统生物学
计算生物学
代谢组学
模式生物
细胞代谢
代谢网络
舱室(船)
新陈代谢
生物信息学
细胞
生物化学
遗传学
酶
基因
海洋学
地质学
作者
Xuhang Li,L. Şafak Yılmaz,Albertha J.M. Walhout
标识
DOI:10.1016/j.coisb.2021.100407
摘要
In multicellular organisms, metabolism is compartmentalized at many levels, including tissues and organs, different cell types, and subcellular compartments. Compartmentalization creates a coordinated homeostatic system where each compartment contributes to the production of energy and biomolecules that the organism needs to carry out specific metabolic tasks. Experimentally studying metabolic compartmentalization and metabolic interactions between cells and tissues in multicellular organisms is challenging at a systems level. However, recent progress in computational modeling provides an alternative approach to this problem. Here, we discuss how integrating metabolic network modeling with omics data offers an opportunity to reveal metabolic states at the level of organs, tissues and, ultimately, individual cells. We review the current status of genome-scale metabolic network models in multicellular organisms, methods to study metabolic compartmentalization in silico, and insights gained from computational analyses. We also discuss outstanding challenges and provide perspectives for the future directions of the field.
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