核酸
脂质体
适体
纳米技术
药物输送
生物相容性
生物传感器
材料科学
组合化学
化学
生物
生物化学
分子生物学
冶金
作者
Hao Yu,Zhihong Liang,Longjiao Zhu,Can Zhao,Xiaoyun He,Keren Chen,Wentao Xu
标识
DOI:10.1002/admi.202101246
摘要
Abstract Liposomes with excellent biocompatibility have been widely used in nutraceutical and biomedical fields for delivery of bioactive molecules. Functional nucleic acids including aptamers that have good target recognizing ability and molecular assembly properties can be used to modify liposomes to expand their applications. This review comprehensively summarizes and comparatively discusses the construction strategies including covalent methods, noncovalent methods, and protein‐mediated methods for fabricating nucleic acid‐modified liposomes. Their applications in stability enhancement, biosensing, drug delivery, and synthesis of biomimetic structures are then reviewed. From above, it is concluded that the nucleic acid‐modified liposome, as a newly developed advanced material, has a good potential to be applied for biosensor or pharmaceutical purposes.
科研通智能强力驱动
Strongly Powered by AbleSci AI