足细胞
线粒体
糖尿病肾病
生物能学
生物
疾病
发病机制
细胞生物学
内科学
医学
肾
内分泌学
免疫学
蛋白尿
作者
Irena Audzeyenka,Agnieszka Bierżyńska,Abigail C Lay
出处
期刊:Endocrinology
[The Endocrine Society]
日期:2021-11-16
卷期号:163 (1)
被引量:24
标识
DOI:10.1210/endocr/bqab234
摘要
Diabetic nephropathy (DN) is the leading cause of kidney failure, with an increasing incidence worldwide. Mitochondrial dysfunction is known to occur in DN and has been implicated in the underlying pathogenesis of disease. These complex organelles have an array of important cellular functions and involvement in signaling pathways, and understanding the intricacies of these responses in health, as well as how they are damaged in disease, is likely to highlight novel therapeutic avenues. A key cell type damaged early in DN is the podocyte, and increasing studies have focused on investigating the role of mitochondria in podocyte injury. This review will summarize what is known about podocyte mitochondrial dynamics in DN, with a particular focus on bioenergetic pathways, highlighting key studies in this field and potential opportunities to target, enhance or protect podocyte mitochondrial function in the treatment of DN.
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