Ferulic Acid, A Component of Angelica Tenuissima Root Extract Induces Anti‐Melanogenic and Anti‐Oxidative Effects

Angelica tenuissima Nakai (Umbelliferae) has been used as a traditional medicine in Asia. The present study investigated the anti‐oxidative and anti‐melanogenic effects of ferulic acid (FA) derived from A. tenuissima root extract (ATE). Anti‐melanogenic activity was determined by intracellular melanin content and tyrosinase activity in α‐MSH (melanin stimulating hormone)‐stimulated B16F10 cells. The anti‐oxidative property of FA was measured using the 2,2‐diphenyl‐1‐picrylhydrazyl (DPPH) and 2,2′‐azino‐bis(3‐ethylbenzothiazoline‐6‐sulfonic acid) (ABTS) scavenging free radical activity assays. FA significantly suppressed the production of melanin and the tyrosinase activity in α‐MSH‐induced cells. FA also showed the significant tyrosinase inhibitory activity and the DPPH/ABTS radical scavenging activities under cell‐free conditions. These results suggest that FA is responsible for the whitening effect of ATE and could be used as an ingredient in cosmeceutical skincare products. This abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .