6,7-双乙酰化黄芩素在大鼠体内的代谢产物研究

To investigate the metabolites of baicalein 6,7-diacetate in rats.HPLC-DAD and LC/MSn methods were used to analyze the metabolites in intestinal tract and plasma after oral administration of baicalein 6,7-diacetate to rats.Baicalein 6,7-diacetate was degraded into baicalein 6-monoacetate and baicalein in rat intestinal tract,and four baicalein glucuronides,baicalein 6-O- glucuronide,baicalein 6-methoxyi-7-O-glucuronide,baicalein 6,7-di-O-glucuronide,and baicalein 6-O-glucose-7-O-glucuronide were detected and tentatively identified in rat plasma.This is the first time to report the metabolites of baicalein 6,7-diacetate in rats.Six metabo|ites were identified in rat intestinal tract and plasma.