结缔组织增生
医学
二甲双胍
癌症
乳腺癌
药理学
癌症研究
生物信息学
胰腺癌
内科学
生物
胰岛素
作者
Tania Nandi,Sai K. Pradyuth,Arihant Kumar Singh,Deepak Chitkara,Anupama Mittal
标识
DOI:10.1016/j.drudis.2020.09.008
摘要
Desmoplasia is a major barrier to chemotherapy in several cancers, particularly pancreatic ductal adenocarcinoma and breast cancer. Tumors comprise of cellular and noncellular components and chemoresistant cancer stem cells (CSCs) with established signaling pathways. In this review, we discuss drugs, such as pentoxifylline, aspirin, and metformin, that have been repurposed and investigated for their antidesmoplastic activity in combination with antitumor drugs. We also highlight less explored new small-molecule drugs, and gene and peptide-based therapeutics for the treatment of desmoplasia and to target CSCs. Promising results from preclinical studies have encouraged several clinical trials to evaluate these antidesmoplastic agents as adjunct to chemotherapy.
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