限制
药物开发
靶向治疗
癌症
医学
生物
癌症治疗
癌症治疗
药品
生物信息学
药理学
内科学
机械工程
工程类
作者
Liang Chang,Paloma Ruiz,Takahiro Ito,William R. Sellers
出处
期刊:Cancer Cell
[Elsevier]
日期:2021-04-01
卷期号:39 (4): 466-479
被引量:68
标识
DOI:10.1016/j.ccell.2020.12.008
摘要
Despite remarkable successes in the clinic, cancer targeted therapy development remains challenging and the failure rate is disappointingly high. This problem is partly due to the misapplication of the targeted therapy paradigm to therapeutics targeting pan-essential genes, which can result in therapeutics whereby efficacy is attenuated by dose-limiting toxicity. Here we summarize the key features of successful chemotherapy and targeted therapy agents, and use case studies to outline recurrent challenges to drug development efforts targeting pan-essential genes. Finally, we suggest strategies to avoid previous pitfalls for ongoing and future development of pan-essential therapeutics.
科研通智能强力驱动
Strongly Powered by AbleSci AI