Efficient Continuous-Flow Synthesis and Evaluation of Anticancer Activity of Novel Quinoline–Pyrazoline Derivatives

An efficient and simple continuous-flow synthetic protocol for novel quinoline-tethered pyrazoline derivatives, which involves condensation of 2-chloroquinoline-3-carbaldehydewith arylmethyl ketones followed by cyclisation with phenyl hydrazine, was developed. The newly synthesized pyrazolines were characterized by IR, 1H and 13C NMR spectroscopy, mass spectrometry, and elemental analysis and tested for anticancer activity against A375 (melanoma), MCF7 (breast), and HT-29 (colon) cell lines. Some of the newly synthesized derivatives showed a higher activity than the control drug Doxorubicin.