荧光
化学
共轭体系
量子产额
近红外光谱
纳米技术
光学
聚合物
材料科学
物理
有机化学
作者
Kun Dou,Wei Feng,Chun‐Lin Fan,Yu Cao,Yunhui Xiang,Zhihong Liu
标识
DOI:10.1021/acs.analchem.0c04990
摘要
Activatable second near-infrared (NIR-II) fluorescent probes that can be lighted up by specific targets have attracted great attention because of their high specificity and resolution, which hold great promise in deep-tissue imaging. However, such probes were relatively rarely reported so far, and the emission maximum is still limited (mainly located at 900–1000 nm). To solve the problem, herein, we proposed a flexible strategy to modulate the emission wavelength of NIR-II fluorescent probes, and four proof-of-concept probes (WH-1, WH-2, WH-3, and WH-4) based on D−π-A molecular skeleton were obtained. These probes can be activated by H2S and the emission maximum located from 925 to 1205 nm, which was attributed to the cooperation of elongating the π-conjugated system and enhancing the electron-donating ability of the donor region. In these probes, WH-3 exhibited the combination of long excitation/emission (925/1140 nm) and moderate quantum yield as well as high sensitivity toward H2S, enabling us to track and image H2S in vivo with high contrast. We expected that such a molecular design strategy will become an important approach to developing activatable NIR-II fluorescent probes with long emission.
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