Study on the DAZ Genes Deletion of the patients with male spermatogenic failure

Objective:To study the relationship between AZFc/DAZ gene deletion and male spermatogenic failure.Methods:DAZ gene region of Y chromosome were detected by Multi-PCR technique in 217 azoospermia,89 oligozoospermia patients and 60 normal fertile men.Results:Among the306 patients,32 patients had been found with DAZ microdeletion,including 21 azoospermia(9.68%) and 11 oliozoospermia(12.36%).The deletion of ZFX/Y,sY84 and sY86 gene was not found.The deletion of DAZ were not found in 60 normal fertile men.Conclusion:DAZ gene is one of the important candidates for azoospermia factor(AZF).Microdeletion on DAZ gene is a major cause of azoospermia and oligozoospermia which lead to male infertility.