替莫唑胺
下调和上调
癌症研究
表观遗传学
胶质母细胞瘤
NF-κB
医学
生物
免疫学
遗传学
炎症
基因
作者
Xinyi Liao,Ziwen Li,Haiqing Zheng,Wanying Qian,Shuxia Zhang,Suwen Chen,Xincheng Li,Miaoling Tang,Yingru Xu,Ruyuan Yu,Man Li,Libing Song,Jun Li
标识
DOI：10.1158/1541-7786.mcr-22-1012
摘要
BASP1 downregulation promotes temozolomide resistance in gliomas through WDR5/MLL complex-mediated epigenetic activation of the FBXO32/NF-κB/MGMT axis, providing new target for improving outcomes in patients with temozolomide-resistant gliomas.
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