JAK inhibitors: a novel, safe, and efficacious therapy for pyoderma gangrenosum

Abstract Background Pyoderma gangrenosum currently lacks standardized therapy. New safer and more efficacious therapies are welcome. Aims To present two new PG cases treated with JAK inhibitors, adding to the small existing experience Methods & Methods Two case reports of PG patients successfully treated with tofacitinib and baricitinib. Results Both patients were cured and presented no relapse. Patient # 1 used baricitinib 2 mg bid for 39 days while patient # 2 was treated with tofacitinib 5 mg bid for 120 days. No adverse reactions were seen. Discussion The increasing usage of JAKi to treat inflammatory diseases had a positive reflex on PG therapy. Fifteen PG cases treated with these drugs had been found in literature and the two new cases here described add to the limited existing experience. Conclusion This is a novel use of tofacitinib and baricitinib beyond the approved indications. JAKi are a welcome addition to our options to manage patients with PG.