医学
周围神经病变
发病机制
内质网
机制(生物学)
外周神经系统
外围设备
炎症
血脂异常
神经营养因子
雪旺细胞
神经营养素
内科学
糖尿病
病理
内分泌学
中枢神经系统
细胞生物学
受体
哲学
认识论
生物
作者
Jingjing Li,Ruiqian Guan,Limin Pan
出处
期刊:Medicine
[Ovid Technologies (Wolters Kluwer)]
日期:2023-01-06
卷期号:102 (1): e32653-e32653
被引量:8
标识
DOI:10.1097/md.0000000000032653
摘要
Diabetic peripheral neuropathy (DPN) is the most common neuropathy in the world, mainly manifested as bilateral symmetry numbness, pain or paresthesia, with a high rate of disability and mortality. Schwann cells (SCs), derived from neural ridge cells, are the largest number of glial cells in the peripheral nervous system, and play an important role in DPN. Studies have found that SCs are closely related to the pathogenesis of DPN, such as oxidative stress, endoplasmic reticulum stress, inflammation, impaired neurotrophic support and dyslipidemia. This article reviews the mechanism of SCs in DPN.
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