Innovative Pyrazole Hybrids: A New Era in Drug Discovery and Synthesis

吡唑 化学 混合的 抗菌剂 组合化学 戒指(化学) 计算生物学 有机化学 生物 植物
作者
Anjaneyulu Bendi,Poonam Devi,Harsh P. Sharma,Geetanjali Yadav,Neera Raghav,Rashmi Pundeer,Mozhgan Afshari
出处
期刊:Chemistry & Biodiversity [Wiley]
被引量:3
标识
DOI:10.1002/cbdv.202402370
摘要

Heterocyclic compounds that include nitrogen and their derivatives have long been regarded as excellent sources of medicinal substances. Pyrazole is a compound with two nitrogen atoms and an aromatic structure. It has several uses and intricate stereochemistry arranged in a five‐membered ring. The knowledge of different pyrazole derivatives and their range of physiological and pharmacological actions has grown significantly in recent years. The scientific community has recently increasingly focused on exploring the chemistry of various pyrazole hybrids due to their enhanced biological activities. This review investigates the chemistry of these diverse pyrazole hybrids, emphasizing their synthesis and their antidiabetic, antibacterial, anticancer, antimicrobial, antioxidant, and anti‐inflammatory activities. Articles published from 2014 onwards with an emphasis on the last five years are included in this review. This review is anticipated to be useful for future investigations and innovative concepts in the pursuit of designs for creating more promising hybrids of pyrazoles.
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