囊性纤维化
医学
药物输送
药品
重症监护医学
药代动力学
药理学
内科学
纳米技术
材料科学
作者
Akshay Parihar,Bhupendra G. Prajapati,Himanshu Paliwal,Mukesh I Shukla,Dignesh Khunt,Sumedh Bahadure,Sathish Dyawanapelly,Vijayabhaskarreddy Junnuthula
标识
DOI:10.1016/j.drudis.2023.103729
摘要
Cystic fibrosis (CF), a fatal genetic condition, causes thick, sticky mucus. It also causes pancreatic dysfunction, bacterial infection, and increased salt loss. Currently available treatments can improve the patient’s quality of life. Drug delivery aided by nanotechnology has been explored to alter the pharmacokinetics and toxicity of drugs. In this short review, we aim to summarize various conventional formulations and highlight advanced formulations delivered via the pulmonary route for the treatment of CF. There is considerable interest in advanced drug delivery formulations addressing the various challenges posed by CF. Despite their potential to be translated for clinical use, we anticipate that a considerable amount of effort may still be required for translation to the clinic.
科研通智能强力驱动
Strongly Powered by AbleSci AI