瓜氨酸化
瓜氨酸
组蛋白
精氨酸
化学
细胞生物学
生物
生物化学
基因
氨基酸
作者
Yan Teng,Yuhang Chen,Xinyi Tang,Shengjun Wang,Kai Yin
标识
DOI:10.1016/j.bbcan.2023.188931
摘要
Peptide arginine deiminase 2(PAD2) catalyzes the conversion of arginine residues on target proteins to citrulline residues in the presence of calcium ions. This particular posttranslational modification is called citrullination. PAD2 can regulate the transcriptional activity of genes through histone citrullination and nonhistone citrullination. In this review, we summarize the evidence from recent decades and systematically illustrate the role of PAD2-mediated citrullination in tumor pathology and the regulation of tumor-associated immune cells such as neutrophils, monocytes, macrophages and T cells. Several PAD2-specific inhibitors are also presented to discuss the feasibility of anti-PAD2 therapy to treat tumors and the urgent problems to be solved. Finally, we review some recent developments in the development of PAD2 inhibitors.
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