Supramolecular Co-Amorphous Quercetin-Piperine Microspheres for Enhanced Bioaccessibility and Synergistic Neuroprotection

The poor aqueous solubility and low bioavailability of natural nutraceuticals, such as quercetin (QUE) and piperine (PIP), limit their healthcare efficacy on Alzheimer's disease (AD).This study developed carrier-free co-amorphous microspheres (CAM-MPs) of QUE and PIP via solvent co-evaporation to address these challenges.Supramolecular interactions (hydrogen bonding, van der Waals forces)