新生
免疫学
炎症
淋巴系统
免疫系统
自身免疫
生物
免疫
先天性淋巴细胞
糖尿病
内分泌学
小岛
作者
Francesca Aloisi,Ricardo Pujol-Borrell
出处
期刊:Nature Reviews Immunology
[Springer Nature]
日期:2006-03-01
卷期号:6 (3): 205-217
被引量:798
摘要
The frequent observation of organized lymphoid structures that resemble secondary lymphoid organs in tissues that are targeted by chronic inflammatory processes, such as autoimmunity and infection, has indicated that lymphoid neogenesis might have a role in maintaining immune responses against persistent antigens. In this Review, we discuss recent progress in several aspects of lymphoid neogenesis, focusing on the similarities with lymphoid tissue development, the mechanisms of induction, functional competence and pathophysiological significance. As more information on these issues becomes available, a better understanding of the role of lymphoid neogenesis in promoting chronic inflammation might eventually lead to new strategies to target immunopathological processes.
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