Quercetin regulates organic ion transporter and uromodulin expression and improves renal function in hyperuricemic mice

Background Renal organic ion transporters and uromodulin (UMOD) play the important roles in renal urate excretion and function. Hyperuricemia is considered as a risk factor for the development of renal dysfunction. The flavonoid quercetin in diets exerts the hypouricemic and nephroprotective effects.