Impact of azithromycin on oropharyngeal carriage of Group A Streptococcus and nasopharyngeal carriage of macrolide-resistant Streptococcus pneumoniae

Azithromycin is an effective short course regimen for eradication of oropharyngeal GAS. However, azithromycin selected for macrolide-resistant strains of pneumococci. These findings highlight the importance of determining the appropriate circumstances for antimicrobial prophylaxis to prevent invasive GAS infections.