血脑屏障
炎症
中枢神经系统
医学
蛋白酵素
基质金属蛋白酶
神经科学
细胞粘附分子
免疫学
细胞生物学
生物
生物化学
酶
内科学
作者
Aubrey A. Webb,Gillian D. Muir
标识
DOI:10.1111/j.1939-1676.2000.tb02248.x
摘要
The unique microenvironment within the central nervous system (CNS) relies upon the integrity of the blood-brain barrier (BBB). This selectively permeable barrier comprises interendothelial tight junctions located at the capillaries and postcapillary venules. Cells and structures in the local environment are required to maintain normal BBB function. When inflammation is present, the BBB itself plays an integral role in the inflammatory response by either producing or expressing a variety of cytokines, adhesion molecules, metalloproteinases, serine proteases, products of arachidonic acid metabolism, and nitric oxide. Understanding the role of the BBB during inflammation is essential when creating and employing a therapeutic regime for animals with CNS disease. This review focusses on recent discoveries about the BBB and its role in inflammation, and applies this knowledge to our current understanding of inflammatory CNS disease in dogs and cats.
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