拟南芥
生物
基因表达
计算生物学
表达式(计算机科学)
拟南芥
基因表达调控
基因表达谱
基因
遗传学
细胞生物学
计算机科学
突变体
程序设计语言
作者
Siobhán M. Brady,David A. Orlando,Ji‐Young Lee,Jean Y. Wang,Jeremy D. Koch,José R. Dinneny,Daniel Mace,Uwe Ohler,Philip N. Benfey
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2007-11-02
卷期号:318 (5851): 801-806
被引量:1053
标识
DOI:10.1126/science.1146265
摘要
Transcriptional programs that regulate development are exquisitely controlled in space and time. Elucidating these programs that underlie development is essential to understanding the acquisition of cell and tissue identity. We present microarray expression profiles of a high-resolution set of developmental time points within a single Arabidopsis root and a comprehensive map of nearly all root cell types. These cell type-specific transcriptional signatures often predict previously unknown cellular functions. A computational pipeline identified dominant expression patterns that demonstrate transcriptional similarity between disparate cell types. Dominant expression patterns along the root's longitudinal axis do not strictly correlate with previously defined developmental zones, and in many cases, we observed expression fluctuation along this axis. Both robust co-regulation of gene expression and potential phasing of gene expression were identified between individual roots. Methods that combine these profiles demonstrate transcriptionally rich and complex programs that define Arabidopsis root development in both space and time.
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