化学
羟基化
二甲基亚砜
催化作用
溶剂
亚砜
组合化学
有机化学
酶
作者
Yu‐Feng Liang,Kai Wu,Song Song,Xinyao Li,Xiaoqiang Huang,Ning Jiao
出处
期刊:Organic Letters
[American Chemical Society]
日期:2015-02-04
卷期号:17 (4): 876-879
被引量:132
摘要
An efficient method for the direct preparation of high synthetic valuable α-hydroxycarbonyls is described. The simple and readily available I2 or NBS was used as catalyst. DMSO acts as the oxidant, oxygen source, and solvent. A diverse range of tertiary Csp3-H bonds as well as more challenging secondary Csp3-H bonds could be hydroxylated in this transformation. The reaction is mild, less toxic and easy to perform.
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