Ultrabubble: A Laminated Ultrasound Contrast Agent with Narrow Size Range

A laminated shell microcapsule is described resisting aggregation and withstanding ultrasound destruction, showing a good backscatter signal, as shown in the figure. Templated synthesis produces versatile monodisperse capsules <3 µm, with ultrasound-pressure dependency allowing rupture above MI ∼ 1.5 (at 2 MHz), suitable for future development as both controlled-delivery agent and contrast agent.