促炎细胞因子
炎症
衰老
生物
表型
转录因子
免疫系统
DNA损伤
免疫学
平衡
细胞生物学
小RNA
染色质
分泌物
激酶
遗传学
DNA
基因
内分泌学
作者
Adam Freund,Arturo V. Orjalo,Pierre‐Yves Desprez,Judith Campisi
标识
DOI:10.1016/j.molmed.2010.03.003
摘要
Chronic inflammation is associated with aging and plays a causative role in several age-related diseases such as cancer, atherosclerosis and osteoarthritis. The source of this chronic inflammation is often attributed to the progressive activation of immune cells over time. However, recent studies have shown that the process of cellular senescence, a tumor suppressive stress response that is also associated with aging, entails a striking increase in the secretion of proinflammatory proteins and might be an important additional contributor to chronic inflammation. Here, we list the secreted factors that make up the proinflammatory phenotype of senescent cells and describe the impact of these factors on tissue homeostasis. We also summarize the cellular pathways/processes that are known to regulate this phenotype--namely, the DNA damage response, microRNAs, key transcription factors and kinases and chromatin remodeling.
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