骨质疏松症
破骨细胞
骨吸收
骨质疏松症
生物
病态的
遗传性疾病
功能(生物学)
细胞生物学
内分泌学
内科学
遗传学
免疫学
医学
受体
基因
作者
Steven L. Teitelbaum,F. Patrick Ross
摘要
Osteoclasts are the principal, if not exclusive, bone-resorbing cells, and their activity has a profound impact on skeletal health. So, disorders of skeletal insufficiency, such as osteoporosis, typically represent enhanced osteoclastic bone resorption relative to bone formation. Prevention of pathological bone loss therefore depends on an appreciation of the mechanisms by which osteoclasts differentiate from their precursors and degrade the skeleton. The past five years have witnessed important insights into osteoclast formation and function. Many of these discoveries have been made through genetic experiments that involved the rare hereditary disorder osteopetrosis.
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