伤害感受器
神经科学
肥大细胞
炎症
感觉系统
神经源性炎症
医学
免疫学
伤害
生物
受体
P物质
神经肽
内科学
作者
James Meixiong,Lilian Basso,Xinzhong Dong,Nicolas Gaudenzio
标识
DOI:10.1016/j.tins.2020.01.001
摘要
Recent studies revealed the existence of unique functional links between mast cells and nociceptors in the skin. Here, we propose that mast cells and nociceptors form a single regulatory unit in both physiology and disease. In this model, MrgprB2/X2 signaling is a primary mechanism by which mast cells functionally interact with nociceptors to form specialized neuroimmune clusters that regulate pain, inflammation, and itch. Recent studies revealed the existence of unique functional links between mast cells and nociceptors in the skin. Here, we propose that mast cells and nociceptors form a single regulatory unit in both physiology and disease. In this model, MrgprB2/X2 signaling is a primary mechanism by which mast cells functionally interact with nociceptors to form specialized neuroimmune clusters that regulate pain, inflammation, and itch.
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