民族
马来语
肠道微生物群
人口学
微生物群
肠道菌群
横断面研究
生物
医学
遗传学
免疫学
人类学
语言学
哲学
病理
社会学
作者
Jacky Dwiyanto,Md Hamed Hussain,Daniel D. Reidpath,Kuan Shion Ong,Aisha A Qasim,S. W. H. Lee,S. M. Lee,Su Chern Foo,Chun Wie Chong,Sadequr Rahman
标识
DOI:10.1038/s41598-021-82311-3
摘要
Abstract No studies have investigated the influence of ethnicity in a multi-ethnic middle-income country with a long-standing history of co-habitation. Stool samples from 214 Malaysian community members (46 Malay, 65 Chinese, 49 Indian, and 54 Jakun) were collected. The gut microbiota of the participants was investigated using 16S amplicon sequencing. Ethnicity exhibited the largest effect size across participants (PERMANOVA Pseudo-F = 4.24, R 2 = 0.06, p = 0.001). Notably, the influence of ethnicity on the gut microbiota was retained even after controlling for all demographic, dietary factors and other covariates which were significantly associated with the gut microbiome (PERMANOVA Pseudo-F = 1.67, R 2 = 0.02, p = 0.002). Our result suggested that lifestyle, dietary, and uncharacterized differences collectively drive the gut microbiota variation across ethnicity, making ethnicity a reliable proxy for both identified and unidentified lifestyle and dietary variation across ethnic groups from the same community.
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